ISAN2017 SCIENTIFIC PROGRAM (English)

 Program at a Glance (Preliminary)

Day 1: Wednesday, August 30

8:30-9:20 Plenary Lecture 1
Cardiac Receptors: Inhibitory, Excitatory and Everything in Between
Irving Zucker (University of Nebraska, USA)
9:30-11:30 Symposium
S1 : New insights into the autonomic nervous system degeneration in multiple system atrophy
Chairs : Tetsutaro Ozawa (Japan)
Masato Asahina (Japan)

  1. Spectrum of the autonomic nervous system degeneration in multiple system atrophy
    Tetsutaro Ozawa (Japan)
  2. Effect of autonomic dysfunction on survival in multiple system atrophy
    Han-Joon Kim (Korea)
  3. New insights into autonomic dysfunction and sleep disorder in MSA
    Pietro Cortelli (Italy)
S2 : Cardiorespiratory control in health and disease
Chairs : Thomas Dick (USA)
Yoshitaka Oku (Japan)

  1. The coupling of cardiorespiratory rhythms in health and disease
    Thomas Dick (USA)
  2. Vagal control of left ventricular excitability and contractility
    Nephtali Marina-Gonzalez (UK)
  3. GABA/Glycine Co-Transmission in the Cardiorespiratory Network
    Swen Hülsmann (Germany)
  4. Amplified respiratory drive to RVLM C1 neurons underlies the altered respiratory-sympathetic coupling and hypertensive phenotype of the SHR rat
    Simon McMullan (Australia)
S3 : Autonomic nervous dysfunction in sleep related disorders
Chairs : Yuichi Inoue (Japan)
Keisuke Suzuki (Japan)

  1. Change in heart rate variability associated with periodic limb movements during sleep
    Taeko Sasai-Sakuma (Japan)
  2. Autonomic dysfunction in patients with Narcolepsy-cataplexy
    Yuichi Inoue (Japan)
  3. Autonomic impairments in rapid eye movement sleep behavior disorders
    Takashi Nomura (Japan)
  4. Autonomic changes in sleep apnea syndrome
    Keisuke Suzuki (Japan)
  5. Carotid body chemosensory potentiation is crucial for the autonomic dysfunction and hypertension induced by intermittent hypoxia mimicking obstructive sleep apnea
    Rodrigo Iturriaga (Chile)
13:00-15:00 Symposium
S4 : Recent advances of dysautonomia in Parkinson's disease
Chairs : Hisayoshi Oka (Japan)
Hirohisa Watanabe (Japan)

  1. Pathophysiology of cardiovagal and sympathoneural failure-Part 1 pathological view
    Makoto Takahashi (Japan)
  2. Gastrointestinal dysfunction in Parkinson's disease
    Masaaki Hirayama (Japan)
  3. Sudomotor research in Parkinson's disease: past, present, and future
    Masato Asahina (Japan)
S5 : Participation of glial cells on the cardiorespiratory regulation
Chairs : Yasumasa Okada (Japan)
Jouji Horiuchi (Japan)

  1. Astrocytes are actively involved in respiratory rhythm generation, hypoxic ventilatory responses and pathogenesis of blood pressure elevation
    Yasumasa Okada (Japan)
  2. PACAP, autonomic neurons and glial cells in cardiorespiratory regulation
    Paul Pilowsky (Australia)
  3. Astroglial control of the CNS cardiorespiratory networks
    Nephtali Marina-Gonzalez (UK)
  4. Astrocytes play a crucial role in enhanced sympathetic outflow in heart failure
    Yoshitaka Hirooka (Japan)
S6 : Oriental Medicine and the Autonomic Nervous System
Chairs : Sae Uchida (Japan)
Hiromi Yamamoto (Japan)

  1. Update on Mechanisms Underlying Peripheral and Central Neural Actions in Acupuncture Autonomic Cardiovascular Regulation
    John Longhurst (USA)
  2. Effect of acupuncture on cardiac and renal sympathetic nerve activities
    Hiromi Yamamoto (Japan)
  3. Spinal mechanism of analgesic effects of acupuncture in the rat models of persistent pain
    Sungtae Koo (Korea)
  4. Mechanism of acupuncture effect on chemotherapy-induced peripheral neuropathy
    Shintaro Ishikawa (Japan)
15:30-17:30 Symposium
S7 : Catecholaminergic Denervation in Autonomic Synucleinopathies
Chair : David S. Goldstein (USA)

  1. Autotoxicity links catecholaminergic denervation with alpha-synucleinopathy in Lewy body diseases
    David S. Goldstein (USA)
  2. Mechanisms of 3,4-dihydroxyphenylacetaldehyde (DOPAL) toxicity include oligomerization and quinonization of alpha-synuclein
    Yehonatan Sharabi (Israel)
  3. Clinico-pathologic correlations between cardiac sympathetic denervation and alpha-synuclein aggregates in Lewy body diseases
    Satoshi Orimo (Japan)
  4. Sympathetic denervation in synucleinopathies, therapeutic implications
    Horacio Kaufmann (USA)
S8 : Targeting the autonomic nervous system to alleviate inflammatory disorders
Chairs : Bruno Bonaz (France)
Yvette Taché (USA)

  1. Cholinergic modulation of inflammation
    Valentin Pavlov (USA)
  2. The splanchnic anti-inflammatory pathway: The efferent arm of the inflammatory reflex?
    Davide Martelli (Australia/Italy)
  3. Brain-gut peptides and vagal anti-inflammatory reflex
    Yvette Taché (USA)
  4. Electroceuticals: Vagus nerve stimulation for inflammatory disorders: clinical trials in inflammatory bowel disease, rheumatoid arthritis and post-operative ileus
    Bruno Bonaz (France)
S9 : Neuro-urology and Autonomic Nervous System: a Diversity of Autonomic Bladder Disorders
Chairs : Ryuji Sakakibara (Japan)
Tatsuya Yamamoto (Japan)

  1. Overview of autonomic bladder disorders
    Jalesh Panicker (UK)
  2. Autonomic bladder disorders in dementia including DLB
    Ryuji Sakakibara (Japan)
  3. Autonomic bladder disorders in stroke
    Tomoyuki Uchiyama (Japan)
  4. Autonomic bladder disorders in Parkinson's disease
    Livia Brusa (Italy)
  5. Autonomic bladder disorders in multiple system atrophy and progressive supranuclear palsy
    Tatsuya Yamamoto (Japan)

Day 2: Thursday, August 31

8:30-9:20 Plenary Lecture 2
Molecular mechanisms of nociception and thermosensation through TRP channels
Makoto Tominaga (Okazaki Institute for Integrative Bioscience, Japan)
9:30-11:30 Symposium
S10 : Basic and clinical Insights into oxytocin's effects on augmenting autonomic and anti-stress activity
Chairs : Yoshiyuki Kuroiwa (Japan)
Kevin Shoemaker (Canada)

  1. New insights into mechanisms regulating central release of neuropeptides and their actions on the autonomic nervous system
    Javier Stern (USA)
  2. Tapping the Oxytocin Factor with Kampo - Results from an Open-Label, Single-Arm, Single-Center, Exploratory Study to Evaluate the Safety and Efficacy of TSUMURA Kamikihito Extract Granules for Ethical Use (TJ-137)
    Hiroyuki Kobayashi (Japan)
  3. Antistress effects of Kampo medicine Kamikihito in rats subjected to restraint stress
    Masataka Sunagawa (Japan)
  4. Kamikihito activates oxytocin neurons in the paraventricular nucleus of the hypothalamus
    Kenju Shimomura (Japan)
  5. Effects of traditional kampo medicine, kamikihito on acute/chronic nociceptive stress in rats
    Takashi Maruyama(Japan)
  6. Oxytocin involvement of μ-opioid receptor-mediated analgesia and relationship between functions of oxytocin and kamikihito, a Japanese Kampo
    Yasuhito Uezono (Japan)
S11: Hot topics
13:00-15:00 Symposium
S12 : New insights in brain renin-angiotensin-aldosterone system, and its critical role in cardiovascular diseases
Chairs : Frans Leenen (Canada)
Yumei Feng (USA)

  1. Role of CNS aldosterone - MR in cardiovascular disease
    Frans Leenen (Canada)
  2. Emerging role of (pro)renin receptor in autonomic regulation of neurogenic hypertension
    Yumei Feng (USA)
  3. Aminopeptidase a Inhibitors as Central-Acting Antihypertensive Agents: From Discovery to Clinical Traials
    Catherine Llorens-Cortes (France)
  4. Immunity and sympathetic nervous system in hypertension and heart failure: Role of brain AT1 receptors
    Yohsitaka Hirooka (Japan)
S13 : Neurovisceral remodeling in disease - Translational potential for Neuromodulation Therapy
Chair : Jeffrey L. Ardell (USA)

  1. Stellate ganglia and regulation of cardiac control - implications for arrhythmias and progression into heart failure
    Kalyanam Shivkumar (USA)
  2. Development of sympathetic circuits regulating energy expenditure and susceptibility to obesity
    Lori Zeltzer (USA)
  3. Stellate ganglia remodeling in cardiac disease - foundational aspects of neural network remodeling
    David Paterson (UK)
  4. Novel signaling pathways in cardiopulmonary systems in health and disease
    Stephen Lewis (USA)
  5. Cardiac neural remodeling and potential for sudden cardiac death
    Keiichi Fukuda (Japan)
15:30-17:30 Symposium
S14 : Recent Developments in Autonomic Circulatory Control During Exercise
Chairs : Erin Howden (Australia)
Justin Lawley (USA)

  1. Metaboreflex Regulation of Sympathetic Activity at Altitude in Lowlanders and Sherpa
    Craig Steinback (Canada)
  2. Regulation of sympathetic tone at rest and activity - implications on functional capacity and survival
    William Cornwell III (USA)
  3. Centrally acting angiotensin converting enzyme inhibitor and antioxidants attenuate the central sympathetic outflow during dynamic exercise in humans
    Gilbert Moralez (USA)
  4. Lack of ipsilateral metaboreflex from contracting muscle: evidence from directing recording of sympathetic nerve activity to contracting muscle
    Vaughan Macefield (Australia)
S15 : Pinpointing the origins of baroreflex gain and set-points
Chair : John P. Horn (USA)

  1. Where in the CNS should we look, and how does it work?
    Robin M. McAllen (Australia)
  2. Baroreflex sensitivity and set-point: It starts with the afferents
    Mark W. Chapleau (USA)
  3. Interaction between intracranial pressure and the sympathetic nervous system; a new link between the brain and the cardiovascular system
    Simon Malpas (New Zealand)
  4. Lessons from single synapses in sympathetic ganglia
    John P. Horn (USA)

Day 3: Friday, September 1

8:30-9:20 Plenary Lecture 3
How reliable is cerebral blood flow to map changes in neuronal activity?
Edith Hamel (McGill University, Canada)
9:30-11:30 Symposium
S16 : Assessment of Human Autonomic Cardiovascular Control: New Approaches to Answer Old Questions
Chair : Can Ozan Tan (USA)

  1. Identification of cortical and subcortical sites involved in the generation of muscle sympathetic nerve activity through MSNA-coupled fMRI
    Vaughan G. Macefield (Australia)
  2. Assessment of cardiac autonomic control by ambulatory electrocardiogram (ECG)
    Junichiro Hayano (Japan)
  3. Methodological Approaches to Assessment of Autonomic Control of Peripheral Circulation
    Kevin Shoemaker (Canada)
  4. Approaches to Quantification of Autonomic Control of Cerebral Circulation
    Can Ozan Tan (USA)
S17 : Central circuitries controlling autonomic physiological response to stressful events
Chairs : Youichirou Ootsuka (Australia)
Rodrigo Alvim Cunha de Menezes (Brazil)

  1. New insights on the lateral habenula: its contribution to the emotional hyperthermia
    Youichirou Ootsuka (Australia)
  2. New insights on Amygdala: The role of Basomedial Amygdala on the regulation of the autonomic and behavioral response to social stress
    Rodrigo Alvim Cunha de Menezes (Brazil)
  3. Contribution of serotonergic neurons in the defense response
    Tomoyuki Kuwaki (Japan)
13:00-15:00 Symposium
S18 : Physiologic Mechanisms of Human Cerebrovascular Regulation in Health and Disease: An Integrated Perspective
Chairs : J. Andrew Taylor (USA)
Can Ozan Tan (USA)

  1. Neurogenic and Regional Mechanisms of Cerebral Autoregulation in Health and Disease
    Can Ozan Tan (USA)
  2. Cerebrovascular Control in Response to Changes in Blood Gases
    Shigehiko Ogoh (Japan)
S19 : Challenges to reveal autonomic functions by novel techniques
Chairs : Yoichi Ueta (Japan)
Hironobu Morita (Japan)

  1. Sleep, hypoxia, arousal and cardiovascular control: Mechanistic insights from rodents using optogenetics
    Peter Burke (Australia/USA)
  2. C1 neurons mediate a stress-induced protection of renal ischemia/reperfusion injury
    Chikara Abe (Japan)
  3. Novel transgenic rat lines regulating the neuronal activity in rat vasopressin neuron by using Optogenetics and DREADDs technology
    Mitsuhiro Yoshimura (Japan)
  4. Measurement of neuronal activity in conscious animal by in vivo photometory system
    Akira Yamashita (Japan)
16:10-18:10 Symposium
S20: Autonomic nervous system disorders in Migraine and Trigeminal autonomic cephalalgias (TACs)
Chairs : Nobuo Araki (Japan)
Hisanori Kowa (Japan)

  1. Autonomic nervous system disorders in mgraine
    Nobuo Araki (Japan)
  2. Autonomic dysfunction in trigeminal autonomic cephalalgias (TACs)
    Hisanori Kowa (Japan)
  3. Short-lasting unilateral neuralgiform headache
    Noboru Imai (Japan)
  4. Cluster headache like symptoms due to sinusitis
    Takao Takeshima (Japan)
S21 : Neuro-immune physiology and pathophysiology
Chairs : Makoto Kadowaki (Japan)
Wouter de Jonge (Netherlands)

  1. Daikenchuto, a Japanese herbal medicine inhibited macrophages infiltration through α7nACh receptor on intestnal macrophages in postoperative ileus
    Masatoshi Hori (Japan)
  2. Various TLRs ligands activate isolated mouse enteric neurons and PLC is involved in TLR4 signaling pathway
    Hanako Ogata (Japan)
  3. Adrenergic nerves control lymphocyte trafficking and adaptive immune responses
    Kazuhiro Suzuki (Japan)
  4. Regulation of mucosal immunity via vagal and sympathetic pathways
    Wouter de Jonge (Netherlands)
18:20-20:20 Poster discussion

Day 4: Saturday, September 2

8:30-9:20 Plenary Lecture 4
Novel Central Regulation of Brown Adipose Tissue Thermogenesis
Shaun Morrison (Oregon Health and Science University, USA)
9:30-11:30 Symposium
S22 : Roles of peripheral serotonergic receptors and purinergic receptors
Chairs : Miyako Takaki (Japan)
Gary M. Mawe (USA)

  1. Pro- and anti-inflammatory roles of 5-HT and its receptors in the gut
    Gary M. Mawe (USA)
  2. Micro-coordination of pacemaker potentials may characterize functional states of gut motility
    Shinsuke Nakayama (Japan)
  3. Neuronal anti-inflammatory signaling via 5-HT4 receptor stimulation in small intestine
    Masatoshi Hori (Japan)
  4. Signal transmission via purinergic receptors to sensory nerves from mechanical stimulation of bone or joints
    Keiji Asada (Japan)
S23 : Autonomic dysfunction in dementia
Chairs : Hitoshi Shimada (Japan)
Shigeki Hirano (Japan)

  1. Autonomic dysfunction in dementia - overview
    Masaaki Hirayama (Japan)
  2. Neuropathological background of autonomic dysfunction in dementia
    Shigeo Murayama (Japan)
  3. Autonomic and cognitive impairment based on basal ganglia dysfunction
    Kaoru Takakusaki (Japan)
13:00-15:00 Symposium
S24 : Infection fever, neurogenic fever and psychogenic fever: how are they different?
Chair : Kazuhiro Nakamura (Japan)

  1. Mediators of infection-induced fever and associated mood alteration
    David Engblom (Sweden)
  2. Central mechanism of neurogenic fever
    Kiyoshi Matsumura (Japan)
  3. Difference in central circuit mechanisms of infection-induced and psychogenic fever
    Kazuhiro Nakamura (Japan)
S25 : Interactions between Pain and the Autonomic Nervous System
Chairs : Harumi Hotta (Japan)
Mathieu Piché (Canada)

  1. Neural mechanisms involved in the noxious stress-induced inhibition of ovarian estradiol secretion
    Sae Uchida (Japan)
  2. Optogenetic and chemogenetic dissection of the essential role of the parabrachial nucleus in the nociception-emotion link
    Fusao Kato (Japan)
  3. Neurovascular coupling during nociceptive processing in the spinal cord of the rat
    Mathieu Piché (Canada)